Inhibition of 4-hydroxyphenylpyruvate dioxygenase by sethoxydim, a potent inhibitor of acetyl-coenzyme A carboxylase

Bioorg Med Chem Lett. 1999 Feb 22;9(4):551-4. doi: 10.1016/s0960-894x(99)00036-0.

Abstract

Sethoxydim, a commercially available cyclohexanedione class herbicide by targeting the enzymatic activity of acetyl-coenzyme A carboxylase, has been found to moderately inhibit the activity of 4-hydroxyphenylpyruvate dioxygenase, a key enzyme in the biosynthesis of plastoquinones and tocopherols in plants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Hydroxyphenylpyruvate Dioxygenase / antagonists & inhibitors*
  • Acetyl-CoA Carboxylase / antagonists & inhibitors*
  • Animals
  • Cyclohexanones / pharmacology*
  • Enzyme Inhibitors / pharmacology*
  • Herbicides / pharmacology*
  • Liver / drug effects
  • Liver / enzymology
  • Swine

Substances

  • Cyclohexanones
  • Enzyme Inhibitors
  • Herbicides
  • sethoxydim
  • 4-Hydroxyphenylpyruvate Dioxygenase
  • Acetyl-CoA Carboxylase